Recent advances in spatial multi-omics have transformed the ability to dissect the complexity of the tumor microenvironment (TME). Dr. Wei’s lab integrates cutting-edge spatial multi-omics with advanced computational approaches to investigate how cancer cells exploit phenotypic plasticity to adapt to therapeutic stress. This work aims to elucidate how these adaptive changes evolve within heterogeneous tumors and are modulated by the TME. In this presentation, Dr. Wei will highlight emerging spatial multi-omics technologies and their computational integration, demonstrating how these tools provide novel insights into the biology of combined small-cell lung cancer (c-SCLC)—a very rare and highly aggressive subtype of lung cancer.

Dr. Wei Wei is an Associate Professor at the Institute for Systems Biology and an Andy Hill CARE Distinguished Researcher. His lab leverages systems-level measurements and computational approaches to explore cancer cell plasticity and adaptive drug resistance, focusing on how tumors dynamically respond to therapy and the role of the tumor microenvironment (TME) in this process. To advance both fundamental and translational cancer research, his team develops single-cell and spatial multi-omics technologies and pioneers liquid biopsy-based predictive diagnostics and needle biopsy-driven microtumor functional assays for precision oncology.